~ Shining Collection ~

francoisdelabooo: thesouthernfangirl: Spirit ships it. Spirit...

Fri, 17 May 2013 22:51:40 +0100

francoisdelabooo:

thesouthernfangirl:

Spirit ships it.

Spirit is the majority of the Soul Eater fandom.

bestactress-jennifercarpenter: Omg Deb :( This trailer breaks...

Fri, 17 May 2013 22:48:33 +0100

bestactress-jennifercarpenter:

Omg Deb :( This trailer breaks my heart …

moon83: Piranha Plant sculpture by Jaime Margary Veja o...

Fri, 17 May 2013 18:36:35 +0100

moon83:

Piranha Plant sculpture by Jaime Margary

Veja o processo de criação da escultura:

mymodernmet: Pipe cleaner sculptures by Lauren Ryan Animal...

Fri, 17 May 2013 18:36:25 +0100

mymodernmet:

Pipe cleaner sculptures by Lauren Ryan

Animal sculptures made of nothing more than pipe cleaners that are occasionally cut with scissors.

tastefullyoffensive: 9 Cats Taking Selfies

Fri, 17 May 2013 18:24:39 +0100

tastefullyoffensive:

9 Cats Taking Selfies

earthlynation: Cirque de Tigre

Fri, 17 May 2013 18:24:10 +0100

earthlynation:

Cirque de Tigre

Happy Birthday Taeyang! xxx

Fri, 17 May 2013 18:21:25 +0100

Happy Birthday Taeyang! xxx

agentdalecooper: the bag my necklaces came in was tiny and my dad just looks at me and says “this...

Fri, 17 May 2013 18:20:19 +0100

agentdalecooper: the bag my necklaces came in was tiny and my dad just looks at me and says “this...

THERES ONLY 116 SAND CATS LEFT ON EARTH

Fri, 17 May 2013 18:19:40 +0100

nightbloggerkurloz: thorsgoddess: twingeneticist: THERES ONLY 116 SAND CATS LEFT ON EARTH I’M...

booksdirect: “Reasons to love being alive: Bookcases.”

Fri, 17 May 2013 18:16:21 +0100

booksdirect:

“Reasons to love being alive: Bookcases.”

Kyoto (京都, Kyōto) served as Japan’s capital and...

Fri, 17 May 2013 18:16:15 +0100

Kyoto (京都, Kyōto) served as Japan’s capital and the emperor’s residence from 794 until 1868. It is now the country’s seventh largest city with a population of 1.4 million people and a modern face.

Over the centuries, Kyoto was destroyed by many wars and fires, but due to its historic value, the city was dropped from the list of target cities for the atomic bomb and spared from air raids during World War II. Countless temples , shrines and other historically priceless structures survive in the city today

Source [x]

alphabadwolf: normalness—leads-to—sadness: reasons why i love...

Fri, 17 May 2013 18:15:32 +0100

alphabadwolf:

normalness—leads-to—sadness:

reasons why i love david tennant

videogamenostalgia: Sony Announce Metal Gear Solid: Legacy for...

Fri, 17 May 2013 18:11:44 +0100

videogamenostalgia:

Sony Announce Metal Gear Solid: Legacy for PS3

Exclusive to the PS3, Konami and Kojima Studios partnered with Sony to reveal an exclusive for the PS3 titled Metal Gear Solid: Legacy. It contains eight full games- Metal Gear, Metal Gear 2, Metal Gear Solid, Metal Gear Solid 2: HD Edition, Metal Gear Solid 3: HD Edition, Metal Gear Solid 4, Metal Gear Solid: Peace Walker HD Edition, and Metal Gear Solid: VR Missions. Not only that, but it will include two Ashley Wood Bande Desinee graphic novels that have never been released in North America or Latin America before. Still not convinced? How about the inclusion of a 100 page artbook?

All of this for $49.99. You can pre-order it on Amazon and other retailers.

Photo

Fri, 17 May 2013 18:09:54 +0100

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Fri, 17 May 2013 18:09:45 +0100

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Fri, 17 May 2013 18:09:34 +0100

130517 GD’s Instagram Updates

Fri, 17 May 2013 15:48:20 +0100

130517 GD’s Instagram Updates

Photo

Fri, 17 May 2013 14:45:13 +0100

bossanovabyss: redkun: That episode where you find out that a...

Fri, 17 May 2013 14:44:30 +0100

bossanovabyss:

redkun:

That episode where you find out that a member of the zany villain squad actually has a heartbreaking past, which includes a bit where he pushes himself to perform a feat that has never been done before and has never been done since, all for the sake of love, only to be rejected as a freak.

All three of them have heartbreaking pasts.

Meowth’s was listed above.

James had abusive (at the very least neglectful, but they didn’t care how he was treated so long as he awarded them prestige) parents who had engaged him to a sociopath, who wanted to whip him and change everything about him to be more “presentable.” He ran away and was on the streets for a long time before he finally joined a crime ring.

Jesse was raised by a single mother, and the two of them were so poor that they rarely had actual food; her mother would make her a “feast” out of snow in the winter that Jesse considered to be a treat because that’s how badly they were starving. If the audio dramas are to be believed, Jesse’s mother was also a member of Team Rocket, who disappeared (read: died) on an expedition searching for Mew, leaving Jesse alone. And then Jesse, like James (and Meowth) was so desperate for a means to survive that she (inadvertently?) followed in her mother’s footsteps and joined Team Rocket/a life of crime just to get by.

“Zany villains” they may be, but Jesse, James, and Meowth are the three deepest characters on the show. I love them.

neurosciencestuff: Gene Involved in Neurodegeneration Keeps...

Fri, 17 May 2013 14:35:03 +0100

neurosciencestuff:

Gene Involved in Neurodegeneration Keeps Clock Running

Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.

In a study of the common fruit fly, the researchers found the gene, called Ataxin-2, keeps the clock responsible for sleeping and waking on a 24-hour rhythm. Without the gene, the rhythm of the fruit fly’s sleep-wake cycle is disturbed, making waking up on a regular schedule difficult for the fly.

The discovery is particularly interesting because mutations in the human Ataxin-2 gene are known to cause a rare disorder called spinocerebellar ataxia (SCA) and also contribute to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. People with SCA suffer from sleep abnormalities before other symptoms of the disease appear.

This study linking the Ataxin-2 gene with abnormalities in the sleep-wake cycle could help pinpoint what is causing these neurodegenerative diseases as well as provide a deeper understanding of the human sleep-wake cycle.

The findings will be published May 17 in the journal Science. Ravi Allada, M.D., professor of neurobiology in the Weinberg College of Arts and Sciences, and Chunghun Lim, a postdoctoral fellow in his lab, are authors of the paper.

Period (per) is a well-studied gene in fruit flies that encodes a protein, called PER, which regulates circadian rhythm. Allada and Lim discovered that Ataxin-2 helps activate translation of PER RNA into PER protein, a key step in making the circadian clock run properly.

“It’s possible that Ataxin-2’s function as an activator of protein translation may be central to understanding how, when you mutate the gene and disrupt its function, it may be causing or contributing to diseases such as ALS or spinocerebellar ataxia,” Allada said.

The fruit fly Drosophila melanogaster is a model organism for scientists studying the sleep-wake cycle because the fly’s genes are highly conserved with the genes of humans.

“I like to say that flies sleep similarly to humans, except flies don’t use pillows,” said Allada, who also is associate director for Northwestern’s Center for Sleep and Circadian Biology. The biological timing mechanism for all animals comes from a common ancestor hundreds of millions of years ago.

Ataxin-2 is the second gene in a little more than two years that Northwestern researchers have identified as a core gear of the circadian clock, and the two genes play similar roles.

Allada, Lim and colleagues in 2011 reported their discovery of a gene, which they dubbed “twenty-four,” that plays a role in translating the PER protein, keeping the sleep-wake cycle on a 24-hour rhythm.

Allada and Lim wanted to better understand how twenty-four works, so they looked at proteins that associate with twenty-four. They found the twenty-four protein sticking to ATAXIN-2 and decided to investigate further. In their experiments, reported in Science, Allada and Lim discovered the Ataxin-2 and twenty-four genes appear to be partners in PER protein translation.

“We’ve really started to define a pathway that regulates the circadian clock and seems to be especially important in a specific group of neurons that governs the fly’s morning wake-up,” Allada said. “We saw that the molecular and behavioral consequences of losing Ataxin-2 are nearly the same as losing twenty-four.”

As is the case in a mutation of the twenty-four gene, when the Ataxin-2 gene is not present, very little PER protein is found in the circadian pacemaker neurons of the brain, and the fly’s sleep-wake rhythm is disturbed.